Hemolytic and cytotoxic effects of saponin like compounds isolated from Persian Gulf brittle star (Ophiocoma erinaceus) Elaheh Amini*, Mohammad Nabiuni, Javad Baharara, Kazem Parivar, Javad Asili Developmental Biology, Kharazmi University, Tehran, Iran Biology, Research Center For Applied Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Cell and Developmental Biology, Science and...

ophiocoma erinaceus muller &troschel; (ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. as, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. saponin extraction was conducted using conventional method such as ...

BACKGROUND Anti-cancer potential of marine natural products such as polysaccharides represented therapeutic potential in oncological researches. In this study, total polysaccharide from brittle star [Ophiocoma erinaceus (O. erinaceus)] was extracted and chemopreventive efficacy of Persian Gulf brittle star polysaccharide was investigated in HeLa human cervical cancer cells. METHODS To extract...

Research on the diversity of echinoderms at Drini Beach, Gunung Kidul, Yogyakarta has been conducted from December 2020 to July 2021. This study aimed determine Echinoderm index. The method sampling technique used belt transect with determination by purposive three stations in intertidal zone based substrate variations. Station 1 had coral type, station 2 seagrass and sand type for 3. sample th...

Ophiocoma erinaceus Muller &Troschel (Ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. As the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. Saponin extraction was conducted using conventional method such as fr...

Echinodermata use saponins in chemical defense against pathogens and predators. The molecular mechanisms of antimetastatic effects of brittle star saponins are still unknown. The present study examined antioxidant capacity and invasive ability in HeLa carcinoma cells exposed to brittle star crude saponins. Discolorating methods with DPPH and ABTS and expression of SOD-2 with RT-PCR were used to...

BACKGROUND Marine organisms provide appreciable source of novel bioactive compounds with pharmacological potential. There is little information in correlation with anti-cancer activities of brittle star. In the present study, anti-neoplastic efficacy of Ophiocoma erinaceus methanol extract against human cervical cancer cells was investigated. METHODS The HeLa cells were cultured and exposed t...